International expert consensus on primary systemic therapy in the management of early breast cancer: highlights of the Fourth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2010).
نویسندگان
چکیده
A panel of international breast cancer experts formulated a declaration of consensus regarding many key issues in the use of primary systemic therapy (PST) either in clinical routine or research practice. The attainment of pathological complete response (pCR), defined as no residual invasive tumor in the surgical specimens both in breast and in axillary nodes, is one of the main goals of PST, and pCR can be used as the primary objective in prospective clinical trials. However, pCR is not a reliable endpoint with all treatment approaches, and alternatives such as Ki67 index of the residual invasive disease or after 2 weeks of PST are also potential endpoints. PST has several advantages: breast conservation and the unique opportunity to obtain information on the interaction between treatment and tumor biology. Changes in tumor biology after PST are an early phenomenon; so, an additional core biopsy performed after 14 days from treatment start should be considered in clinical trials.
منابع مشابه
International Expert Consensus on Primary Systemic Therapy in the Management of Early Breast Cancer: Highlights of the Fourth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer,
Aglietta, Massimo, Berruti, Alfredo, Bertolini, Francesco, Bruzzi, Paolo, Conte, PierFranco, Cosimo, Serena, Curigliano, Giuseppe, Daidone, Mariagrazia, Damia, Giovanna, Danova, Marco, Desmedet, Christine, Dowsett, Mitch, E. Mansel, Robert, Fenaroli, Privato, Ferrozzi, Francesco, Generali, Daniele, Gianni, Luca, Kaufmann, Manfred, Kennedy, Derek, Olivetti, Lucio, Petronini, Piergiorgio, Puztai,...
متن کاملSystemic Targeted Alpha Radiotherapy for Cancer
Background: The fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.The high linear energy transfer (LET) of alpha radiation to the targeted cancer cellscauses double strand breaks in DNA. At the same time, the short range radiation spares adjacent normal tissues. This targeted approach complements conventional external beam radiotherapy and ch...
متن کاملCompare the Effectiveness of Systemic-Structurally Oriented Couple Therapy and the Teaching of the Pluralistic Family Communication Model on Marital Satisfaction in Women with Breast Cancer
Purpose: The purpose of this study was to compare the effectiveness of systemic-structurally oriented couple therapy and the teaching of the pluralistic family communication model on marital satisfaction in women with breast cancer. Method: This is a semi-experimental research with pretest-posttest design with control group. The statistical population included all women with breast cancer refer...
متن کاملInternat ional Expert Panel on the Use of Pr imary (
Primary systemic therapy (PST) represents the standard of care in patients with locally advanced breast cancer. In addition, there is increasing information on PST in operable breast disease that supports the use of PST in routine practice. However, current regimens and techniques vary. To address this concern, a group of representatives from breast cancer clinical research groups in France, Ge...
متن کاملTailoring therapies—improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer
Citation Coates, A. S., E. P. Winer, A. Goldhirsch, R. D. Gelber, M. Gnant, M. Piccart-Gebhart, B. Thürlimann, and H.-J. Senn. 2015. “Tailoring therapies—improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015.” Annals of Oncology 26 (8): 1533-1546. doi:10.1093/annonc/mdv221. http://dx.doi.org/10.1093/annonc/md...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of the National Cancer Institute. Monographs
دوره 2011 43 شماره
صفحات -
تاریخ انتشار 2011